履歷(教育及工作经验)

教育：

1. 2005 上海復旦大学医学院临床医学学士
2. 2007 上海復旦大学医学院临床医学硕士
3. 2013 香港理工大学康復治疗科学系博士

工作经验：

1. 2005-2007 上海华山医院手外科实习医生
2. 2008-2008 香港理工大学康復治疗科学系研究助理
3. 2010-2011 美国纽约石溪大学生物医学工程访问学者
4. 2011-2013 香港理工大学康復治疗科学系兼职副研究员
5. 2013-2014 香港中文大学中医学院研究助理
6. 2014-2017 香港中文大学中医学院博士后研究员
7. 2017-2019 香港中文大学中医学院副研究员
8. 2019-2025 香港中文大学中医学院研究助理教授
9. 2025至今 香港中文大学中医学院助理教授

科研范围

1. 针对肿瘤及肌肉骨骼系统疾病的分子机理探索及基于中医药天然产物和适配子的药物开发研究
2. 天然产物转化研究
3. 基于适配子的组织靶向药物递送

着作及论文（选列)

1. Chen Z, Zhang N, Chu HY, Yu Y, Zhang ZK*, Zhang G, Zhang BT. Connective Tissue Growth Factor: From Molecular Understandings to Drug Discovery. Front Cell Dev Biol 2020;8:593269. DOI:10.3389/fcell.2020.593269.
2. Zheng Y, Wang X, Zhang ZK#, Guo B, Dang L, He B, Zhang C, Zhou J, Shi W, Zhao Y, Zhan H, Xu Y, Liang C, Liu J, Guan D, Wang L, Wu X, Li J, Zhuo Z, Lin Z, Qiu H, Zhong L, Bian Z, Shi Y, Zhang BT, Zhang G, Lu A. Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial. Sci Rep 2019;9(1):2089. DOI:10.1038/s41598-018-38335-3.
3. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. Long Noncoding RNA lncMUM
A Reverses Established Skeletal Muscle Atrophy following Mechanical Unloading. Mol Ther 2018;26(11):2669-80. DOI:10.1016/j.ymthe.2018.09.014.
4. Zhang ZK, Li J, Guan D, Liang C, Zhuo Z, Liu J, Lu A, Zhang G, Zhang BT. A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. J Cachexia Sarcopenia Muscle 2018;9(3):613-26. DOI:10.1002/jcsm.12281.
5. Liang C, Li F, Wang L, Zhang ZK#, Wang C, He B, Li J, Chen Z, Shaikh AB, Liu J, Wu X, Peng S, Dang L, Guo B, He X, Au DWT, Lu C, Zhu H, Zhang BT, Lu A, Zhang G. Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma. Biomaterials 2017;147:68-85. DOI:10.1016/j.biomaterials.2017.09.015.
6. Zhang ZK, Guo X, Lao J, Qin YX. Effect of capsaicin-sensitive sensory neurons on bone architecture and mechanical properties in the rat hindlimb suspension model. J Orthop Translat 2017;10:12-7. DOI:10.1016/j.jot.2017.03.001.
7. Guo B, Zhang ZK#, Liang C, Li J, Liu J, Lu A, Zhang BT, Zhang G. Molecular Communication from Skeletal Muscle to Bone: A Review for Muscle-Derived Myokines Regulating Bone Metabolism. Calcif Tissue Int 2017;100(2):184-92. DOI:10.1007/s00223-016-0209-4.
8. He B, Zhang ZK#, Liu J, He YX, Tang T, Li J, Guo BS, Lu AP, Zhang BT, Zhang G. Bioinformatics and Microarray Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms for Impaired Fracture Healing. Int J Mol Sci 2016;17(8):E1260. DOI:10.3390/ijms17081260.
9. Zhang ZK, Li J, Liu J, Guo B, Leung A, Zhang G, Zhang BT. Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading. Sci Rep 2016;6:20300. DOI:10.1038/srep20300.
10. Zhang ZK, Li J, Yan DX, Leung WN, Zhang BT. Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization. Int J Mol Sci 2016;17(2):E169. DOI:10.3390/ijms17020169.